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""Purpose It��s known that severe inflammatory processes may cause limbal stem cell (SC) deficiency decreasing the number of SC niches and changing the microanatomy of these structures. Methods The aim of this study was to evaluate the expression of different SC markers in normal human limbus and to study how an inflammatory conditions can modulate these antigens. To understand the pathological changes in limbal crypts structure due to severe inflammation, a case of corneal melting and perforation Duvelisib in advanced herpes simplex (HSV) disease, two cases of endophthalmitis and a case of fungal infection were analyzed.Samples were examined by immunohistochemistry or immunofluorescence for p63, vimentin, laminin5, integrin (Int) ��6, int ��1, int ��4, ABCG2, desmoglein 3, connexin43, N-cadherin and cytokeratin (K) 12 positivity. We evaluated the anatomical structure of limbal crypts in each SB431542 manufacturer case and the positivity for SC marker used to identify SC. Results In normal limbus, the investigated SC markers were positive. In the HSV we didn��t observe presence of crypts, whereas in both cases of endophthalmitis crypts were still present but they had an atypical structure: the basal cells in the crypts were ��stretched�� and endowed by inflammatory cells. In the pathological cases, we observed positivity for K12 while, among SC markers, p63, ABCG2 and connexin43 were still present; the others antigens were variably expressed. Conclusion Different pathologies involving the limbus may result in marked chenges of expression of SC markers within the crypts. ""Purpose To correlate spectral-domain optical coherence tomography (SD-OCT) characteristics of macular edema (ME) due to retinal vein occlusion (RVO) with mean best corrected visual acuity (BCVA). Methods Fifty patients (50 eyes) having macular edema due to CRVO or BRVO, were retrospectively reviewed Statistical analysis was used to evaluate the relative contribution of several variables, including SD-OCT characteristics such as baseline central retinal thickness (CRT), central intraretinal cyst size, serous retinal Alpelisib nmr detachment (SRD) size, photoreceptor inner segment/outer segment (IS/OS) integrity and external limiting membrane (ELM) status with mean BCVA. Results Thirty three patients had BRVO (66%), 14 patients (28%) had CRVO and 3 patients (6%) had HVO. Mean CRT was 574,52 ?m. There was a strong correlation between CRT and visual acuity (CCP=0,41 ; P=0,003). Cystoid macular edema was present in 46 eyes (92%) with central intraretinal cyst in 36 eyes (72%). Mean BCVA was statistically better in eyes without central intraretinal cyst (P=0,015) but there was not a significant difference depending of the cyst size (CCP=0,28 ; P=0,09). SRD occurred in 22 eyes (44%) and mean thickness of SRD was 237?m. Mean BCVA was statistically better in eyes without SRD (P<0,001) but there was not a significant difference depending of the cyst size (CCP=0,27 ; P=0,21).
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