Endobronchial Metastasis

Osteosarcoma is the most common primary skeletal malignancy of childhood, typically occurring between the ages of 10 and 20 years. For patients treated with surgery alone or with surgery and adjuvant chemotherapy, pulmonary metastases are frequently seen (80%) as a relapse.2 However, metastatic malignancy rarely involves a major airway. The most common extrathoracic tumors associated with endobronchial metastasis are renal, breast, and colorectal carcinomas. Other reported primary tumors include melanoma, soft tissue sarcomas, and tumors of the uterine cervix, testis, ovary, prostate, thyroid, pancreas, and adrenal glands. Previously, only one case of endobronchial metastasis from osteosarcoma of the bone has been reported. We report such a case, highlighting the peculiar appearance of the endobronchial mass and a good clinical response to intraluminal radiotherapy (ILT).

Case Report

A 21-year-old man presented with a 2-month history of gradually increasing dyspnea, nonproductive cough, and wheeze. He gave a history of weight loss of about 15 kg over a year. He also reported 2 days of fever. canadian pharmacy

Approximately 3 years (34 months) before his current problems occurred, the patient had pain and swelling in the left knee, which on excision biopsy had been proved to be caused by an osteosarcoma of the bone.